Nod2 Mutation in Crohn's Disease Potentiates NF-κB Activity and IL-1ß Processing

Autor:	Michael Karin, Martin F. Kagnoff, Hongjun Liu, Shin Maeda, Laurie A. Bankston, Mitsutoshi Iimura, Lars Eckmann, Li-Chung Hsu
Rok vydání:	2005
Předmět:	Multidisciplinary medicine.medical_treatment NF-κB IκB kinase Biology medicine.disease Inflammatory bowel disease digestive system diseases chemistry.chemical_compound Cytokine chemistry NOD2 Immunology medicine Cancer research Secretion Muramyl dipeptide Intracellular
Zdroj:	Science. 307:734-738
ISSN:	1095-9203 0036-8075
DOI:	10.1126/science.1103685
Popis:	Variants of NOD2, an intracellular sensor of bacteria-derived muramyl dipeptide (MDP), increase susceptibility to Crohn's disease (CD). These variants are thought to be defective in activation of nuclear factor κB (NF-κB) and antibacterial defenses, but CD clinical specimens display elevated NF-κB activity. To illuminate the pathophysiological function of NOD2, we introduced such a variant to the mouse Nod2 locus. Mutant mice exhibited elevated NF-κB activation in response to MDP and more efficient processing and secretion of the cytokine interleukin-1β (IL-1β). These effects are linked to increased susceptibility to bacterial-induced intestinal inflammation and identify NOD2 as a positive regulator of NF-κB activation and IL-1β secretion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6493532d85be6d580e02871616201679 https://doi.org/10.1126/science.1103685 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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