Fas mRNA EXPRESSION IN BLOOD IS REDUCED DURING EPISODES OF HUMAN CORNEAL GRAFT REJECTION1

Autor:	I. Reynolds, Eleftheria Zeggini, JA Dixon, AB Tullo, M. C. Hillarby
Rok vydání:	2001
Předmět:	Transplantation Messenger RNA Corneal Transplant Biology eye diseases Pathogenesis Andrology medicine.anatomical_structure Apoptosis Cornea Immunology Gene expression medicine sense organs Complication
Zdroj:	Transplantation. 71:702-705
ISSN:	0041-1337
DOI:	10.1097/00007890-200103150-00024
Popis:	BACKGROUND: Our purpose is to examine levels of Fas mRNA expression in blood during human corneal transplant rejection. METHODS: Fas mRNA expression was detected by reverse transcription-PCR in blood from normal controls, corneal recipients at the time of transplantation and during episodes of rejection. RESULTS: Samples taken at the time of a corneal rejection episode showed Fas mRNA levels were significantly lower in these patients than either normal controls (P = 0.017) or corneal transplant recipients not undergoing graft rejection (P = 0.00052). Serial samples from five patients who suffered an episode of rejection showed that the level of Fas mRNA is reduced during the rejection episode and subsequently recovers. CONCLUSIONS: These results indicate low levels of Fas mRNA in blood may have a role in corneal transplant rejection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::64912a7e7f896751822c587224995078 https://doi.org/10.1097/00007890-200103150-00024 Zobrazit plný text záznamu