Effect of Colla corii asini (E’jiao) on D-Galactose Induced Aging Mice
| Autor: | Chen Zhuo, Hongyan Xu, Fengshan Wang, Yan Zhang, Yan-Na Cheng, Maoxuan Liu, Dongliang Wang, Jichao Cao, Jian Zhang, Shousheng Tian |
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| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Antioxidant biology Chemistry media_common.quotation_subject medicine.medical_treatment Glutathione peroxidase Pharmaceutical Science Appetite General Medicine Malondialdehyde Superoxide dismutase Blot chemistry.chemical_compound Catalase Gene expression biology.protein medicine media_common |
| Zdroj: | Biological and Pharmaceutical Bulletin. 35:2128-2132 |
| ISSN: | 1347-5215 0918-6158 |
| Popis: | Colla corii asini (E'jiao), donkey-hide gelatin prepared by stewing and concentrating from Equus asinus L. donkey hide, is a traditional Chinese medicine preparation widely used in clinical hematic antanemic therapy in China. The aim of the present study was to investigate potential anti-aging effect of Colla corii asini and explore related mechanisms in D-galactose (gal) induced aging model mice. The mice were artificially induced aging by subcutaneously injection with D-gal at the dose of 100 mg/kg·d for 8 weeks. Colla corii asini was simultaneously treated to them once daily by intragastric gavage. Appetite, mental condition, body weight, and organ index were observed. Activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), as well as levels of malondialdehyde (MDA) in serum, brain, and liver were determined by according assay kits. Western blotting analysis was used to detect p16 and p21 expression. Results indicated that Colla corii asini could improve appetite, mental condition, body weight, and organ condition of model mice, improve SOD, CAT, and GSH-Px activities, reduce MDA levels, and modulate age-related genes expression in D-gal induced mice. Therefore, Colla corii asini may have effect to suppress the aging process through enhancing antioxidant activity, scavenging free radicals, and modulating aging-related gene expression. |
| Databáze: | OpenAIRE |
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