Keggin and Dawson-type polyoxometalates as efficient catalysts for the synthesis of 3,4-dihydropyrimidinones: experimental and theoretical studies
| Autor: | Baya Boutemeur-Khedis, Malika Makhloufi-Chebli, Chérifa Rabia, Leila Dermeche, Maamar Hamdi, Artur M. S. Silva, Liza Saher |
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| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Reaction conditions Reaction mechanism 010405 organic chemistry Organic Chemistry Biginelli reaction Condensation 010402 general chemistry 01 natural sciences Biochemistry Aldehyde 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Drug Discovery Polymer chemistry Organic chemistry Acetonitrile |
| Zdroj: | Tetrahedron Letters. 57:1492-1496 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2016.02.077 |
| Popis: | 3,4-Dihydropyrimidinones were synthesized by a multicomponent condensation of an aldehyde, a β-keto ester, and urea, in acetonitrile and ethanol using Keggin and Dawson type polyoxometalates as catalysts. Keggin heteropolyacid, H 4 SiMO 12 O 40 , is more efficient compared to Keggin and Dawson salts and to the Biginelli classical reaction conditions. It leads to good yields and short reaction times. Theoretical calculations let us to confirm the reaction mechanism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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