Asymmetric synthesis of amines using a chiral, non-racemic, cyclic sulphinamide

Autor: David R.J. Hose, Martin Wills, Tony M. Raynham
Rok vydání: 1993
Předmět:
Zdroj: Tetrahedron: Asymmetry. 4:2159-2162
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(00)80065-8
Popis: The homochiral cyclic sulphinamide S(S)R-(+)-1 has been employed in the asymmetric synthesis of α-methylbenzylamine via the benzylidene sulphinamide R(S)Ri-(−)-3. Following diastereoselective reduction and hydrolysis S(S)R-(+)-1 can be recycled in one step from the sulphinic acid 6.
Databáze: OpenAIRE