A symmetry-driven approach to the putative spiroketal core of the didemnaketals

Autor:	Allen G. Oliver, Benoît Moreau, Jason A. Davy, Jeremy E. Wulff
Rok vydání:	2015
Předmět:	Stereochemistry Chemistry Organic Chemistry Drug Discovery Human immunodeficiency virus (HIV) medicine Enantioselective synthesis medicine.disease_cause Biochemistry Function (biology) 3. Good health
Zdroj:	Tetrahedron. 71:2643-2657
ISSN:	0040-4020
DOI:	10.1016/j.tet.2015.03.043
Popis:	Didemnaketals A and B are isolation artifacts whose exact structures have been the subject of recent controversy. Although the biological function of the presumed progenitor—didemnaketal C—remains unknown, both degradation products are inhibitors of HIV protease, and are believed to function through an unusual dissociative mechanism. Other didemnaketals (D and E) have antibacterial activity. As a step towards better understanding the chemistry and biology of the didemnaketals, this report describes the efficient asymmetric synthesis of their putative spiroketal core from a meso-precursor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::647294861d4d71034e853036725111f1 https://doi.org/10.1016/j.tet.2015.03.043 Zobrazit plný text záznamu Full Text from ScienceDirect