Polymorphism in Piroxicam
| Autor: | Simon Bates, Agam R. Sheth, Francis X. Muller, David J.W. Grant |
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| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | Crystal Growth & Design. 4:1091-1098 |
| ISSN: | 1528-7505 1528-7483 |
| DOI: | 10.1021/cg049876y |
| Popis: | Piroxciam is a polymorphic drug. However, reports on the number and nomenclature of the polymorphs of piroxicam and the complete hydrogen-bonding patterns of piroxicam molecules in the crystal forms are in conflict and are sources of confusion, which we attempt to clarify. The difference in energy of the two polymorphs, I and II, of piroxicam arises predominantly from the difference between their lattice energies, rather than between their conformational energies. The detailed hydrogen-bonding networks of the two polymorphs are described and compared. Despite stabilization of the polymorphs by hydrogen bonds, a loss of polymorphic memory was observed upon cryogrinding the two polymorphs, leading to differences in recrystallization behavior between amorphous piroxicam prepared from polymorphs I and II. |
| Databáze: | OpenAIRE |
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