Determining chemical air equivalency using silicone personal monitors
Autor: | Steven G. O’Connell, Marc I. Epstein, Kim A. Anderson |
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Rok vydání: | 2021 |
Předmět: |
Atmospheric exposure
Empirical data Measure (data warehouse) 010504 meteorology & atmospheric sciences Epidemiology Organic chemicals Public Health Environmental and Occupational Health Vapor generator 010501 environmental sciences Toxicology Atmospheric sciences 01 natural sciences Pollution Boiling point chemistry.chemical_compound Silicone chemistry Exposure chamber Environmental science 0105 earth and related environmental sciences |
Zdroj: | Journal of Exposure Science & Environmental Epidemiology. 32:268-279 |
ISSN: | 1559-064X 1559-0631 |
Popis: | Background Silicone personal samplers are increasingly being used to measure chemical exposures, but many of these studies do not attempt to calculate environmental concentrations. Objective Using measurements of silicone wristband uptake of organic chemicals from atmospheric exposure, create log Ksa and ke predictive models based on empirical data to help develop air equivalency calculations for both volatile and semi-volatile organic compounds. Methods An atmospheric vapor generator and a custom exposure chamber were used to measure the uptake of organic chemicals into silicone wristbands under simulated indoor conditions. Log Ksa models were evaluated using repeated k-fold cross-validation. Air equivalency was compared between best-performing models. Results Log Ksa and log ke estimates calculated from uptake data were used to build predictive models from boiling point (BP) and other parameters (all models: R2 = 0.70–0.94). The log Ksa models were combined with published data and refined to create comprehensive and effective predictive models (R2: 0.95–0.97). Final estimates of air equivalency using novel BP models correlated well over an example dataset (Spearman r = 0.984) across 5-orders of magnitude (5000 ng/L). Significance Data from silicone samplers can be translated into air equivalent concentrations that better characterize environmental concentrations associated with personal exposures and allow direct comparisons to regulatory levels. |
Databáze: | OpenAIRE |
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