Preliminary study to prepare a reference material of toluene metabolite – o-cresol and benzene metabolite-phenol – in human urine

Autor:	M. Tichý, Ilona Šperlingová, Jan Kučera, Vladimír Stránský, Ludmila Dabrowská
Rok vydání:	2006
Předmět:	Chromatography o-Cresol General Chemical Engineering Metabolite General Chemistry Cresol Urine Toluene chemistry.chemical_compound chemistry medicine Phenol Phenols Safety Risk Reliability and Quality Benzene Instrumentation medicine.drug
Zdroj:	Accreditation and Quality Assurance. 11:231-235
ISSN:	1432-0517 0949-1775
DOI:	10.1007/s00769-006-0157-1
Popis:	The candidate reference material (RM) was prepared by freeze-drying pooled urine samples obtained from healthy persons occupationally exposed to toluene. Homogeneity testing yielded no significant differences of urinary concentrations of o-cresol and phenol in 15 randomly selected units of RM. Stability testing showed no significant changes of concentrations of the above analytes over a period of 6 months. Property (pre-certified) values of phenol and o-cresol concentrations and their uncertainties (9.06±0.47 mg l−1 and 1.03±0.06 mg l−1, respectively) were estimated from results of a small-scale interlaboratory comparison in which two laboratories participated using four different analytical methods.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::645e83ba00474d3fe30a9c430447b159 https://doi.org/10.1007/s00769-006-0157-1 Zobrazit plný text záznamu Full text from SpringerLink