Synthesis of functionalised isochromans: epoxides as aldehyde surrogates in hexafluoroisopropanol

Autor: Cyprien Muller, Filip Horký, Marie Vayer, Andrei Golushko, David Lebœuf, Joseph Moran
Rok vydání: 2023
Předmět:
Zdroj: Chemical Science. 14:2983-2989
ISSN: 2041-6539
2041-6520
Popis: The use of epoxides as aldehyde surrogates allows isochromans to be constructed with greater scope than previously reported oxa-Pictet–Spengler reactions. The initial Meinwald rearrangement and subsequent steps are promoted by HFIP and triflic acid.
Databáze: OpenAIRE