| Popis: |
Antibody tests were performed to the sera of 68 normal children in Okayama Prefecture (the Okayama group), where were frequently. found the patients with Cuillain-Barre-Syndrome (G. B. S.), and to the sera of 45 normal children in Ushio Villoge, Oohara District, Shimane Prefecture (the Shimane group), where the G. B. S. rarely occured, by Beeman's virus-dilution method with C. V. Okumoto strain (A2) and Dohi strain (A19) isolated from the patiens with G. B. S..1) The positive rate of neutralizing antibody of the both Okayama-and Shimane groups was very high, showing that the C. V. Dohi-and Okumoto strains were common in Japan, at least in both prefectures.2) The positive rate of the neutralizing antibody by age, was the highest in the children under 6 months and the lowest in those from 7 months to 1 year. The positive rate became higher with age in the Okayama group. The Shimane group showed an earlier ascendence of the rate with age than the Okayama group.3) Concerning the distribution of neutralizing index by age, Dohi-antibody showed a tendency of higher index as children became older in the Okayama group, while others showed various and irregular distribution.4) Neutralizing index in a cord blood showed the same titer to both agents as the mothers serum.5) The co-existence of neutralizing antibodies was investigated, and its positive rate was 56.1% in Okayama group, and 64.5% in Shimane group. From these resulas, the C. V. Dohi-and Okumoto strains are considered to be common in both prefectures and it is difficult to conclude that the C. V. Dohi-and Okumoto strains are the agents of Guillain-Barre Disease, though these viruses have been isolated from the patients. |
