MYOSTATIN LEVEL IN CRF PATIENTS WITH AND WITHOUT POST-HCV CIRRHOSIS AND ITS CORRELATION WITH BMI
| Autor: | Salama Mm, Heba Mahmoud Elfouly, Hagar A Elessawy, Mohamed Ali Makhlouf, Mohamed El Badry |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Cirrhosis biology medicine.diagnostic_test business.industry medicine.medical_treatment Physical examination Myostatin musculoskeletal system medicine.disease Gastroenterology Sarcopenia Internal medicine biology.protein medicine Hemodialysis business Body mass index Dialysis Kidney disease |
| Zdroj: | Journal of the Egyptian Society of Parasitology. 50:315-321 |
| ISSN: | 2090-2549 |
| DOI: | 10.21608/jesp.2020.113053 |
| Popis: | Chronic kidney disease (CKD) is a progressive condition that may negatively affect musculoskeletalhealth. Secondary sarcopenia due to CKD may be associated with mobility limitationsand elevated fall risk. Thus, it is important to investigate surrogate methods that enablethe assessment of muscle mass. Myostatin regulates synthesis and degradation of skeletal muscleproteins and is associated with the development of sarcopenia. This study assessed the myostatinlevel in CKD patients and correlated with body mass index. This a prospective casecontrol study, carried out on 30 Egyptian patients with CKD (15 have post-HCV cirrhosis) attendedfor dialysis in Al-Hammoul Central Hospital and 15 healthy controls. All patients weresubjected to detailed medical history and through clinical examination, abdominal ultrasoundand determination of serum myostatin level. The mean, standard deviation and chi-square werecalculated by SPSS. ROC curves were conducted to test the discriminative value of myostatinlevel on sarcopenia and to detect the cut-off points. The results showed significant increase inthe serum myostatin level in hemodialysis patients. Myostatin level in post-HCV cirrhotic patientswas insignificantly higher than in non-cirrhotic patients. There was a significant negativecorrelation between serum myostatin level and BMI and skeletal muscle index (SMI). ROCcurve showed that a cut off value of 39.05ng/ml can detect sarcopenia in hemodialysis patients. |
| Databáze: | OpenAIRE |
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