Antioedematogenic and anti-inflammatory actions of Phragmanthera incana (Schum) Balle leaf in carrageenan-induced inflammation models in rats
| Autor: | Olushola O. Joseph, Alice O. Oyibo, Akinyinka O. Alabi, Abayomi M. Ajayi |
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| Rok vydání: | 2020 |
| Předmět: |
Exudate
Antioxidant biology medicine.drug_class medicine.medical_treatment Glutathione Pharmacology medicine.disease_cause Malondialdehyde Anti-inflammatory Carrageenan chemistry.chemical_compound Complementary and alternative medicine chemistry Catalase medicine biology.protein medicine.symptom Oxidative stress |
| Zdroj: | Advances in Traditional Medicine. 21:701-711 |
| ISSN: | 2662-4060 2662-4052 |
| Popis: | Phragmanthera incana (Schum) is a specie of mistletoe that has been mentioned in Nigeria ethnomedicine to be used in the treatment of inflammatory disorders. The aim of this study was to investigate the anti-inflammatory effect of Phragmanthera incana leaf ethanol extract (PIEE) in carrageenan-induced inflammation models in rats. In the carrageenan-induced rat paw oedema experiment, 0.1 mL of carrageenan (1%) was injected into the paw one hour after treatment with PIEE (125, 250 and 500 mg/kg). Paw volume was measured hourly for 4 h using the plethysmometer. The anti-inflammatory activity was investigated using the carrageenan-induced air pouch inflammation model. Leucocytes migration and pro-inflammatory mediators (TNF-α and IL-6) were evaluated in the air pouch exudate. Oxidative stress biomarkers (MDA, Nitrite, GSH and Catalase) were estimated in both the carrageenan-induced paw tissue homogenates and air pouch exudate. PIEE (125, 250 and 500 mg/kg) administration significantly (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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