A Brief Overview of Progranulin in Health and Disease
| Autor: | Siu Tim Cheung, Andrew Bateman, Hugh P.J. Bennett |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Mutation business.industry Neurodegeneration Granulin Cancer Inflammation Disease medicine.disease_cause medicine.disease Phenotype 03 medical and health sciences 030104 developmental biology mental disorders medicine medicine.symptom business Neuroscience Frontotemporal dementia |
| Zdroj: | Methods in Molecular Biology ISBN: 9781493985579 |
| DOI: | 10.1007/978-1-4939-8559-3_1 |
| Popis: | The purpose of this brief overview of the progranulin protein is to provide a sense of the range and extent of the roles of progranulin in normal physiology and pathology. Progranulin has received attention due to its role in neurodegeneration, where mutation of a single copy of GRN, the gene encoding progranulin, results in frontotemporal dementia, whereas viral delivery of progranulin to the brains of mice exhibiting Parkinson's or Alzheimer's disease phenotypes inhibits the progression of the neurodegenerative phenotypes. Of equal importance, progranulin protects tissues against the harmful effects of poorly controlled inflammation and promotes tissue regeneration after injury at a multitude of sites throughout the body. Progranulin is overexpressed by many types of cancer and contributes to their progression. Given suitable analytical methods and model systems, progranulin offers a wealth of research possibilities. |
| Databáze: | OpenAIRE |
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