Thyroid Peroxidase: Experimental and Clinical Integration

Autor:	Masao Nakamura, Hidehiko Nakagawa, Tomio Kotani, Sachiya Ohtaki
Rok vydání:	1996
Předmět:	endocrine system biology Mechanism (biology) Endocrinology Diabetes and Metabolism Hormone biosynthesis Thyroid food and beverages Endocrinology medicine.anatomical_structure Thyroid peroxidase Immunology biology.protein Thyroid Follicular Cells medicine Base sequence Neuroscience
Zdroj:	Endocrine Journal. 43:1-14
ISSN:	1348-4540 0918-8959
DOI:	10.1507/endocrj.43.1
Popis:	Since TPO plays a cardinal role in regulating many cellular processes of thyroid hormone biosynthesis in thyrocytes, it is important to present a summary of the impact that TPO research on the basis of molecular structure has had on our understanding of thyroid diseases. This review has therefore been written to highlight the biochemical, molecular biological, immunological and clinical aspects of TPO in thyroid follicular cells. As for hormonogenesis, further details of the properties of the superoxide generating system remain unknown, but based on decisive evidence showing what active iodinating species are at initial and principal stages, a novel concept of the mechanism of two electron oxidation has been put forth. Recent progress in studies of analyses of TPO gene structure has also provided stimuli for renewed investigation into a much wider field of thyroidology, including thyroiditogenesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::641f983afdbb306078b890596e06fe92 https://doi.org/10.1507/endocrj.43.1 Zobrazit plný text záznamu