Efficacy of a Topical Agent, MAS063D (‘Atopiclair’), in the Treatment of Sodium Lauryl Sulphate-Induced Irritant Contact Dermatitis
| Autor: | Hongbo Zhai, Zeba Hasan Hafeez, Howard I. Maibach, Clarissa D. Villarama |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Nonsteroidal business.industry Sodium lauryl sulphate Public Health Environmental and Occupational Health Dermatology Atopic dermatitis medicine.disease body regions chemistry.chemical_compound chemistry Irritant contact dermatitis medicine Itching medicine.symptom business ATOPICLAIR |
| Zdroj: | Exogenous Dermatology. 2:301-305 |
| ISSN: | 1424-4624 1424-4616 |
| DOI: | 10.1159/000081567 |
| Popis: | Background: Irritant contact dermatitis (ICD) is commonly treated with topical corticosteroids. MAS063D (‘Atopiclair’) is a nonsteroidal effective in atopic dermatitis. Objective: To determine the efficacy of a topical agent, MAS063D, in managing ICD. Methods: Two sites of ICD were created using sodium lauryl sulfate (SLS) in 20 volunteers; MAS063D was then applied to one and a vehicle-only control to the other. Measurements were taken at baseline, 24, 48 and 72 h. Results: The objective measurements of blood flow volume (BFV), skin color (a*) and transepidermal water loss (TEWL) all showed statistically significant benefits of MAS063D over the vehicle-only control. BFV and a* were significantly better at all time points (p = 0.046, p = 0.045, respectively, at 72 h) and TEWL at 48 and 72 h (p = 0.02 at 72 h). Conclusion: MAS063D demonstrated benefits over vehicle in three clinically meaningful outcomes of SLS-induced ICD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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