Mitochondrial DNA content and deletion ratio are associated with metabolic syndrome in a general population exposed to pesticide
| Autor: | Sungjin Park, Jae Yeop Kim, Sang Baek Koh, Jung Ran Choi, Sung Kyung Kim, Sung Soo Oh, Kyung-Suk Lee |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Mitochondrial DNA Health Toxicology and Mutagenesis Population Toxicology Pathology and Forensic Medicine law.invention 03 medical and health sciences 0302 clinical medicine law Internal medicine medicine General Pharmacology Toxicology and Pharmaceutics education Prospective cohort study Polymerase chain reaction education.field_of_study business.industry Public Health Environmental and Occupational Health Odds ratio Pesticide medicine.disease Confidence interval 030104 developmental biology Endocrinology 030220 oncology & carcinogenesis Metabolic syndrome business |
| Zdroj: | Molecular & Cellular Toxicology. 16:347-354 |
| ISSN: | 2092-8467 1738-642X |
| Popis: | Mitochondrial DNA (mtDNA) copy number and deletion ratio may be asymmetrically determined using physiologic or pathologic conditions. Mitochondrial dysfunction is associated with an increased risk of developing metabolic syndrome (MetS). Here, we investigated the association between mtDNA copy number and/or deletion ratio and the risk of developing MetS in a general population exposed to the pesticide. We examined 215 randomly sampled adults who were exposed to pesticide but did not present with MetS in a prospective cohort study. Both mtDNA copy number and deletion ratio were determined using quantitative real-time polymerase chain reaction. During the average 2.8-year follow-up period, 76 (35.3%) participants developed new-onset MetS. The numbers of mtDNA copies were significantly lower in participants with new-onset MetS than in those without MetS (112.15 ± 26.15 vs. 133.13 ± 44.44, p |
| Databáze: | OpenAIRE |
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