An Investigation of the Release Properties of a Cationic Drug From a Hydrophobic Polyanhydride Matrix as a Function of Dissolution Medium

Autor:	D. A. Stephens, Y. Tian, L. C. Li, T. D. Stultz, J. E. Quick, H.-C. Chang, E. J. Ginsburg, D. Robinson, R. M. Liu, X. Gao
Rok vydání:	1998
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Gentamicin Sulfate Materials science Ion exchange chemistry Chemical engineering Drug delivery Cationic polymerization Salt (chemistry) Carboxylate Sulfate Dissolution
Zdroj:	MRS Proceedings. 550
ISSN:	1946-4274 0272-9172
Popis:	The dissolution of a drug delivery system consisting of gentamicin sulfate in a hydrophobic polyanhydride matrix has been examined. The in vitro release of gentamicin is a function of the composition of the dissolution medium, with slower release in pH 7.4 buffer than in unbuffered water. This is consistent with an anion exchange taking place under conditions in which carboxylate polymer chain-ends form a poorly soluble salt with gentamicin, and sulfate is released into solution. Results of additional experiments probing this model are digeussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::63f513263ee3041a1c3f6c6dfc7ad46c https://doi.org/10.1557/proc-550-35 Zobrazit plný text záznamu Full text from SpringerLink