68Ga-Pentixafor PET/CT Imaging of Chemokine Receptor CXCR4 in Chronic Infection of the Bone: First Insights
| Autor: | Birgit Meller, Caroline Bouter, Johannes Meller, Hans-Jürgen Wester, Wieland Staab, Carsten Oliver Sahlmann, Saskia Kropf |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
PET-CT
medicine.medical_specialty medicine.diagnostic_test business.industry Osteomyelitis medicine.disease Scintigraphy CXCR4 030218 nuclear medicine & medical imaging 3. Good health 03 medical and health sciences Chronic infection 0302 clinical medicine medicine.anatomical_structure Bone scintigraphy 030220 oncology & carcinogenesis White blood cell medicine Radiology Nuclear Medicine and imaging Radiology Osteitis business |
| Zdroj: | Journal of Nuclear Medicine. 59:320-326 |
| ISSN: | 2159-662X 0161-5505 |
| DOI: | 10.2967/jnumed.117.193854 |
| Popis: | Because of its role in infection and inflammatory processes, the chemokine receptor CXCR4 might be a potent target in imaging of infectious and inflammatory diseases. The aim of this pilot study was to determine whether the CXCR4 ligand 68Ga-pentixafor is suitable for imaging chronic infection of the bone. Methods: The study comprised 14 patients with suspected infection of the skeleton who underwent 68Ga-pentixafor PET/CT between April 2015 and February 2017 in our facility. 68Ga-pentixafor PET/CT results were retrospectively evaluated against a histologic, bacteriologic, and clinical standard. The results were also compared with available bone scintigraphy, white blood cell scintigraphy, and 18F-FDG PET/CT results. Results:68Ga-pentixafor PET/CT was positive in 9 of 14 patients. Diagnoses included osteitis or osteomyelitis of peripheral bone, osteomyelitis of the maxilla, and infected endoprostheses. Target-to-background ratios were 5.1-15 (mean, 8.7). Eight of 9 cases were true-positive as confirmed by pathology, bacteriology, or clinical observation. All negative cases were confirmed as true-negative by other imaging modalities and follow-up. Conclusion: Imaging of CXCR4 expression with 68Ga-pentixafor PET/CT appears suitable for diagnosing chronic infection of the skeleton. The findings of this study reveal a possible diagnostic gain in suspected chronic infections that are difficult to diagnose by other imaging modalities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|