Successful Treatment of High Elevation of Serum Myoglobin by Wash-out Therapy in a Patient with Neuroleptic Malignant Syndrome

Autor:	Naoto Inagaki, Naoki Tsujiguchi, Johji Arakawa, Tetsuo Omote, Tsutomu Furuse, Naoyuki Fujimura, Akiyoshi Namiki, Masatoshi Kotaki
Rok vydání:	1996
Předmět:	Fluphenazine medicine.medical_specialty biology business.industry Serum myoglobin Furosemide medicine.disease Gastroenterology Neuroleptic malignant syndrome Internal medicine Anesthesia medicine biology.protein Creatine kinase Mannitol Intramuscular injection business Rhabdomyolysis medicine.drug
Zdroj:	Nihon Shuchu Chiryo Igakukai zasshi. 3:289-292
ISSN:	1882-966X 1340-7988
DOI:	10.3918/jsicm.3.289
Popis:	A case of neuroleptic malignant syndrome with a high elevation of serum myoglobin was successfully treated by wash-out therapy.A 34-year-old man developed neuroleptic malignant syndrome after an intramuscular injection of fluphenazine. The laboratory examination showed remarkable increases in serum myoglobin and creatine phosphokinase (CPK) (maximum values: 15×104ng·ml-1, 49.7×104IU·l-1, respectively). Continuous infusions of mannitol and furosemide, and volume expansion were carried out to increase urinary flow. Urinary output increased up to 13 liters per day, and serum myoglobin, and CPK decreased dramatically.This case suggested that wash-out therapy was effective in preventing acute renal failure which is often seen in neuroleptic malignant syndrome accompanying a remarkable increase in serum myoglobin.
Databáze:	OpenAIRE
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