| Autor: |
Paavo Honkakoski, Janne Hukkanen, Olavi Pelkonen, Jukka Hakkola, Hannu Raunio, Pirkko Viitala |
| Rok vydání: |
2002 |
| Předmět: |
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| Zdroj: |
Pharmacokinetic Challenges in Drug Discovery ISBN: 9783662043851 |
| DOI: |
10.1007/978-3-662-04383-7_6 |
| Popis: |
Induction is defined as the increase in the amount and activity of a drug-metabolising enzyme, which is a long-term (hours and days) consequence of a chemical exposure. Previously, the study of induction of drug metabolism was largely empirical and phenomenological, and prediction beyond the compounds under actual study was practically impossible. During the last decade, however, and particularly as a consequence of the detailed knowledge obtained about regulatory factors governing the expression and induction of cytochrome P450 (CYP) enzymes, induction can be understood on a detailed mechanistic basis and predictability of pharmacological and toxicological consequences has become possible. Mechanistic understanding provides also a basis for the development of new in vitro methods to measure and predict induction. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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