Combined cryosurgery and cold-responsive drug-loaded nanoparticles to enhance deep-lying tumor therapy: A mathematical model
| Autor: | Xuelan Zhang, Liancun Zheng, Kheder Suleiman, Chang Shu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Fluid Flow and Transfer Processes
Drug Chemotherapy Side effect Chemistry Mechanical Engineering medicine.medical_treatment media_common.quotation_subject Tumor therapy Nanoparticle Cryotherapy 02 engineering and technology 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Cryosurgery 010305 fluids & plasmas 0103 physical sciences medicine Cancer research Doxorubicin 0210 nano-technology medicine.drug media_common |
| Zdroj: | International Journal of Heat and Mass Transfer. 165:120663 |
| ISSN: | 0017-9310 |
| Popis: | Minimally-invasive cryosurgery is incapable of killing the tumor at the outer periphery of iceball, resulting in the inefficiency of tumor treatment. In this paper, we develop a new combined treatment of chemotherapy and cryotherapy (chemo-cryo) by injecting cold-responsive drug-loaded nanoparticles around the tumor before cryosurgery to enhance the treatment of deep-lying tumor. A macroscopic mathematical model is established for the first time, covering the cryosurgery, the release of anti-tumor drug (doxorubicin) from cold-responsive nanoparticles, and the drug transport in biological tissues. Therapeutic efficacy is evaluated in terms of the effective killing volumes of tumor and normal tissue, including cryosurgery killing and drug killing. Simulation results show that comparisons with cryosurgery alone demonstrate the advantage of chemo-cryo treatment in enhancing the therapeutic efficacy, given that the killing volume of normal tissue is lessened by 89.36% for the single-probe and 72.57% for the multi-probe in the case of complete tumor killing. The amount of doxorubicin released is determined by the holding time of cryoprobe, the sensitive temperature and initial concentration of drug-loaded nanoparticles, independent of doxorubicin diffusivity. Adjusting the holding time and the properties of nanoparticles and doxorubicin can augment the effective killing volume of tumor, but it is also accompanied by side effect on normal tissue, mainly manifested as drug killing. Results obtained can serve as the guideline to optimize chemo-cryo treatment regimens for deep-lying tumor. |
| Databáze: | OpenAIRE |
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