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Introduction Individual reaction to medicine is determined by genetic factors. The CYP2D6 gene is involved in the metabolism of 20–25% of medication. The carriage of CYP2D6*10 determines the synthesis of a defective protein with a reduced activity of the CYP2D6 isoenzyme, which determines the difference in interindividual medicine variability and an increased risk of undesirable drug reactions. Distribution of CYP2D6*10 varies in different races and ethnic groups. Methods In 151 Buryat adolescents, DNA was isolated from whole venous blood, the allelic composition was determined by the CYP2D6*10 gene polymorphism (rs1065852). The average age of the subjects was 16.02±2.05 years. Buryats belong to the indigenous people living on the Asian part of Russia. They belong to the Mongoloid race and are part of the small North Asian race. When forming the samples, ethnicity was taken into account in at least three generations. Result Identified carriers of two genotypes rs1065852 CYP2D6*10: SS (70.19%) and CT (29.81%). The prevalence of functional C-allele was 85.1%; non-functional T-allele - 14.9%. When comparing the prevalence of non-functional T-allele rs1065852 CYP2D6*10 with the same indicator in other populations of the world, significant differences with the Mongols (T-allele frequency 55.0%, p Conclusions The presence of significant differences in distribution of non-functional T-allele CYP2D6*10 (rs1065852) in the Buryat population was shown in comparison with some populations of the Mongoloid and Negroid races. |
