The relationship between elastin cross linking and alveolar wall rupture in human pulmonary emphysema

Autor:	Michael Fagiola, Sandra Reznik, Muhammad Riaz, Yibing Qyang, Seoyeon Lee, Joseph Avella, Gerard Turino, Jerome Cantor
Rok vydání:	2023
Předmět:	Pulmonary and Respiratory Medicine Physiology Physiology (medical) Cell Biology
Zdroj:	American Journal of Physiology-Lung Cellular and Molecular Physiology. 324:L747-L755
ISSN:	1522-1504 1040-0605
DOI:	10.1152/ajplung.00284.2022
Popis:	The current findings support the hypothesis that airspace enlargement is an emergent phenomenon in which initial proliferation of DID cross links to counteract alveolar wall distention is followed by a phase transition involving rapid acceleration of elastin breakdown, alveolar wall rupture, and progression to an active disease state that is less amenable to therapeutic intervention.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::63e94f6ff5f4624c9a29adc312772892 https://doi.org/10.1152/ajplung.00284.2022 Zobrazit plný text záznamu