STUDIES IN SICKLE CELL DISEASE
| Autor: | George S. Shields, Herbert C. Lichtman, Jacqueline Messite, R. Janet Watson |
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| Rok vydání: | 1958 |
| Předmět: | |
| Zdroj: | Pediatrics. 22:309-318 |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.22.2.309 |
| Popis: | In newborn infants with sickle cell trait, the percentage of erythrocytes capable of being sickled in vitro gradually rose during the first 4 months of life. A concomitant fall in the percentage of Hgb F was demonstrated. The percentage of cells which could be induced to assume the sickled shape was found not to be correlated with the percentage of Hgb S, but instead was correlated with the reciprocal of the concentration of Hgb F. The specific reaction rate of alkali resistant hemoglobin in the infants less than 3 months of age was found to differ from that found in adults and in infants more than 3 months of age. |
| Databáze: | OpenAIRE |
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