A New Approach Using Aromatic-Solvent-Induced Shifts in NMR Spectroscopy to Analyze β-Lactams with Various Substitution Patterns
| Autor: | María G. Vasquez-Ríos, Blanca Eda Domínguez-Mendoza, Jonathan Román Valdez-Camacho, Luis G. Hernández-Vázquez, Jaime Escalante, Leticia Chavelas-Hernández |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Chloroform
010405 organic chemistry Chemical shift Organic Chemistry Nuclear magnetic resonance spectroscopy 010402 general chemistry Ring (chemistry) 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Computational chemistry Molecule Density functional theory Solvent effects Benzene |
| Zdroj: | Synlett. 31:158-164 |
| ISSN: | 1437-2096 0936-5214 |
| Popis: | The chemical shifts of protons depend not only on the properties of the solute molecule but also on the medium in which the solute resides. A series of β-lactams with various substitution patterns were synthesized to study aromatic-solvent-induced shifts (ASISs) in chloroform and benzene by using 1H NMR spectroscopy. The results agreed with those obtained by theoretical density functional theory calculations. The protons of the β-lactam ring are the most affected by the ASIS effect, and they tend to overlap due to the anisotropic effect of benzene. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|