The role of JAK/STAT signaling pathway and TNF-α crosstalk in human colorectal cancer
| Autor: | Enver Ihtiyar, Rumeysa Ozyurt, Mete Özkurt, Nilüfer Erkasap, Fatih Yaşar, Serdar Erkasap |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
biology business.industry Colorectal cancer JAK-STAT signaling pathway Mouse model of colorectal and intestinal cancer medicine.disease stat 03 medical and health sciences Crosstalk (biology) 030104 developmental biology 0302 clinical medicine Apoptosis 030220 oncology & carcinogenesis Immunology Genetics biology.protein Cancer research Medicine Tumor necrosis factor alpha STAT1 business |
| Zdroj: | Gene Reports. 3:1-4 |
| ISSN: | 2452-0144 |
| Popis: | Colorectal cancer (CRC) constitutes a significant portion of mortality and morbidity due to cancer around the world. The present study was designed to evaluate the possible effects of the JAK/STAT, TNF-α, and NFκB pathways, and the caspase-3 apoptotic marker in human colorectal tissue. Data from tumor tissue and adjacent normal colon tissue (n:12) were obtained. Given the biological role of the JAK/STAT signaling pathway in human colorectal tissue, we evaluated interactions with TNFα, NFκB, and caspase-3. We measured the mRNA levels of STAT1, TNF-α, TNF-α R1A, NFκB, and caspase-3 by RT-PCR. The STAT1, TNF-α, TNF-α R1A, and NFκB mRNA levels were increased in colorectal cancer tissue compared to adjacent normal colon tissue ( P P P P |
| Databáze: | OpenAIRE |
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