Is the blood-CSF barrier altered in disease?
| Autor: | S. Seyfert, A. Faulstich |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Lumbar puncture Albumin General Medicine medicine.disease Blood–brain barrier Gastroenterology Hydrocephalus Central nervous system disease medicine.anatomical_structure Cerebrospinal fluid Lumbar Neurology Internal medicine Immunology medicine Neurology (clinical) business CSF albumin |
| Zdroj: | Acta Neurologica Scandinavica. 108:252-256 |
| ISSN: | 0001-6314 |
| DOI: | 10.1034/j.1600-0404.2003.00119.x |
| Popis: | Objectives – To illustrate the influence of cerebrospinal fluid (CSF) flow on lumbar CSF protein concentration and to test for an altered blood–CSF barrier permeability as additional influence. Patients and methods – Consecutively hospitalized patients with normotensive hydrocephalus (n = 21) underwent lumbar puncture with CSF being sampled in sequential portions. CSF/blood quotients of albumin (QAlb) and of immunoglobulin G (QIgG) were compared intra-individually and with calculated values from a reference patient sample. Results and conclusion – QAlb and QIgG of intra-individual sequential portions correlated highly with each other (median r = 0.95), suggesting lumbar CSF flow as the main thecal determinant of lumbar QAlb and QIgG variation. In addition, QIgG, relative to QAlb, was significantly lower in study patients compared with a reference patient sample (P = 0.002), implying an alteration of the blood–CSF barrier permeability as a minor determinant of QAlb and QIgG variation in study patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|