111In Antifibrin Monoclonal Antibodies in the Evaluation of the Deep Venous Thrombosis of the Lower Limbs: An Italian Multicenter Study

Autor:	L. Lusiani, P. Zanco, R. Spaziante, M. Gallazzo, P. Rossini, E. Brianzoni, L. Feggi
Rok vydání:	1994
Předmět:	medicine.medical_specialty Pathology biology medicine.drug_class business.industry Monoclonal antibody medicine.disease Fibrin Epitope Surgery Duplex scanning Venous thrombosis Multicenter study Popliteal vein medicine biology.protein Antibody business
Zdroj:	Radiolabeled Blood Elements ISBN: 9781461360483
DOI:	10.1007/978-1-4615-2462-5_33
Popis:	From January 1987 and December 1988, a multicenter study has been conducted in Italy by six Nuclear Medicine Departments, in order to establish the value of 111In-labeled antifibrin monoclonal antibody 59D8 (Fibriscint, Centocor) for the diagnosis of deep venous thrombosis (DVT) of the lower limbs. This antibody (a Fab fragment obtained by a murine hybridoma) is highly specific for a defined epitope of the beta chain of human fibrin, and does not cross-react with fibrinogen1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::63d4a4f2a9b96707719cc057a0bd44d4 https://doi.org/10.1007/978-1-4615-2462-5_33 Zobrazit plný text záznamu