ChemInform Abstract: Artificial Synthetic Receptors as Regulators of Protein Activity

Autor:	Som Dutt, Thomas Schrader, Constanze Wilch
Rok vydání:	2011
Předmět:	chemistry.chemical_compound Chemistry Supramolecular chemistry Biophysics Rational design General Medicine NAD+ kinase Receptor Molecular tweezers Small molecule Porphyrin Potassium channel
Zdroj:	ChemInform. 42
ISSN:	0931-7597
DOI:	10.1002/chin.201133265
Popis:	This article discusses most recent work and progress in the direction of a rational design of small molecule receptors that efficiently interfere with the biological function of a particular receptor or enzyme—some of which are therapeutically relevant. More specifically, the following topics are highlighted here: the inhibition of voltage-dependent potassium channels of the Kv1.x family by designed porphyrin and calix[4]arene ligands, the structural and functional recovery of the tetramerization domain of mutated P53 protein by tailored calix[4]arene ligands and the control over LDH activity by supramolecular signaling. Finally a new way to modulate NAD+-dependent enzymatic activities by molecular clips and tweezers is presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::63d2e5898dc3fba148a645801bc77f63 https://doi.org/10.1002/chin.201133265 Zobrazit plný text záznamu Plný text