THE PHOTOPHYSICAL PROBE, 7-AZATRYPTOPHAN, IN SYNTHETIC PEPTIDES

Autor:	J. Li, R. W. Thornburg, K. L. Rich, S. Elliott, Jacob W. Petrich, Michel Negrerie
Rok vydání:	1993
Předmět:	chemistry.chemical_classification Chemistry Stereochemistry Tryptophan Peptide General Medicine 7-azatryptophan Biochemistry Amino acid Protein structure Molecule Physical and Theoretical Chemistry Molecular probe Competitive inhibitor
Zdroj:	Photochemistry and Photobiology. 58:28-30
ISSN:	1751-1097 0031-8655
Popis:	7-Azatryptophan is proposed as an alternative to tryptophan as a photophysical probe in the study of protein structure and dynamics. Not only are the spectral characteristics of 7-azatryptophan easily distinguishable from those of tryptophan, but this nonnatural amino acid is shown to be amenablc to incorporation into peptides. We present the first synthesis and purification of a synthetic peptide containing 7-azatryptophan, NAc-Pro-7-azatryptophan-Asn-NH2, which is shown to be a competitive inhibitor of α-chymotrysin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::63d23184211d36acaa03490fa779e243 https://doi.org/10.1111/j.1751-1097.1993.tb04898.x Zobrazit plný text záznamu Plný text