The role of fetal chromosomal aberrations in the genesis of recurrent and sporadic miscarriage

Autor: S.A. Korostelev, V.V. Kovalev, Yu.K. Kievskaya, Perinatology named after Academician V.I.Kulakov, Moscow, Russian Federation, 'Genomed' Llc, Moscow, Russian Federation, I.I.Baranov I.I.Baranov, E.V. Kudryavtseva, I.V. Kanivets, N. N. Potapov
Rok vydání: 2021
Předmět:
Zdroj: Voprosy ginekologii, akušerstva i perinatologii. 20:34-39
ISSN: 2414-9152
1726-1678
DOI: 10.20953/1726-1678-2021-1-34-39
Popis: Objective. To compare the frequency and nature of embryo/fetus chromosomal abnormalities (CA) in sporadic and recurrent pregnancy loss. Patients and methods. A retrospective cohort study that included 1000 patients with pregnancy loss at 6–12 weeks of gestation. The first group consisted of 681 patients who had their first sporadic miscarriage. The second group consisted of 319 patients who previously had a miscarriage. Chromosomal microarray analysis (CMA) of abortive material was performed. Results. In the first group, various chromosomal abnormalities in the embryo/fetus were detected in 378 (55.5%) samples, in the second group – in 203 (63.5%). The incidence of CA in patients with a history of miscarriage was higher than in sporadic miscarriage, the differences were statistically reliable (p = 0.015). No significant differences were found in the structure of CA. Autosomal trisomies and numerical abnormalities of sex chromosomes were most frequently detected. Conclusion. Chromosomal abnormalities in the embryo are a significant cause of miscarriage, both sporadic and recurrent. Genetic analysis of abortive material is an important component of the examination for choosing further management tactics for patients. CMA is an effective research method when conducting genetic analysis of conception products. Key words: pregnancy loss, preconception planning, recurrent miscarriage, chromosomal abnormalities, chromosomal microarray analysis
Databáze: OpenAIRE
Externí odkaz: