A monocentric therapy study: An approach to optimize the results of the treatment of osteosarcoma by protocols based upon HDMTX, associated with systematic conservative surgery

Autor:	G. Delepine, N. Delepine, J. C. Desbois
Rok vydání:	1993
Předmět:	Protocol (science) medicine.medical_specialty business.industry Poor responder medicine Preoperative chemotherapy Osteosarcoma business medicine.disease Surgery Pharmacokinetic analysis
Zdroj:	Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies ISBN: 9781461365617
DOI:	10.1007/978-1-4615-3518-8_39
Popis:	In order to understand why Rosen’s protocol [1] has not been reproduced by most groups [2, 3, 4, 5] that used the same scheme, we started preliminary study in 1984 using T10 to analyze methotrexate (MTX) pharmacokinetics and its correlations with clinical and histological results. From 1985 to 1989 a second pilot study was conducted to optimize the results of Rosen while conducting a pharmacokinetic analysis to understand the reasons for failures in attempts to reproduce T10 and to emphasize the fundamental points for curing osteosarcomas.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::63c796f7927c1128c7275b6bea2f31fe https://doi.org/10.1007/978-1-4615-3518-8_39 Zobrazit plný text záznamu