| Autor: | N. V. Shishkanova, A. P. Il'chenko, Cherniavskaia Og, Finogenova Tatyana |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
inorganic chemicals
chemistry.chemical_classification biology Glyoxylate cycle Yarrowia Tricarboxylic acid biology.organism_classification Applied Microbiology and Biotechnology Microbiology Malate dehydrogenase Aconitase Citric acid cycle chemistry.chemical_compound chemistry Biochemistry Fumarase Citric acid |
| Zdroj: | Microbiology. 71:269-274 |
| ISSN: | 0026-2617 |
| DOI: | 10.1023/a:1015842308827 |
| Popis: | A comparative study of the enzymes of tricarboxylic acid (TCA) and glyoxylate cycles in the mutant Yarrowia lipolytica strain N1 capable of producing α-ketoglutaric acid (KGA) and citric acid showed that almost all enzymes of the TCA cycle are more active under conditions promoting the production of KGA. The only exception was citrate synthase, whose activity was higher in yeast cells producing citric acid. The production of both acids was accompanied by suppression of the glyoxylate cycle enzymes. The activities of malate dehydrogenase, aconitase, NADP-dependent isocitrate dehydrogenase, and fumarase were higher in cells producing KGA than in cells producing citric acid. |
| Databáze: | OpenAIRE |
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