Augmented Flow-Induced Endothelin Release from the Rat Mesenteric Arterial Bed after Long-Term Sympathectomy
| Autor: | Geoffrey Burnstock, Vera Ralevic, Pamela Milner |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Vasopressin Endothelium Physiology medicine.medical_treatment Substance P Cell Biology General Medicine Adenosine chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Sympathectomy Vasoactive Internal medicine medicine Endothelin receptor Guanethidine medicine.drug |
| Zdroj: | Endothelium. 3:67-73 |
| ISSN: | 1029-2373 1062-3329 |
| DOI: | 10.3109/10623329509024661 |
| Popis: | The effect of long-term guanethidine sympathectomy and short-term 6-hydroxydopamine (6-OHDA) sympathectomy on the release of endothelial vasoactive substances by high flow from the rat mesenteric arterial bed was examined. Preparations were perfused at a constant flow rate of 5 ml/min with Krebs' solution, and at 25 ml/min for 2 min. During increased flow there was a release of adenosine 5′-triphosphate (ATP), endothelin, vasopressin and substance P into the perfusate. In preparations from guanethidine-treated rats the flow-evoked release of endothelin (median: 23.55 pmol/min) was significantly greater than that in the controls (median: 0.37 pmol/min) (P < 0.05). Flow-evoked release of ATP, vasopressin and substance P was similar between the groups. After short-term sympathectomy with 6-OHDA an increase in flow was accompanied by the release of ATP, endothelin, vasopressin and substance P which was not significantly different between control and 6-OHDA treated preparations. These results show that after l... |
| Databáze: | OpenAIRE |
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