Concentration of cisplatin-incorporated polymeric micelles in a murine solid tumor evaluated using PIXE analysis

Autor:	K. Kusano, Seiichi Wada, M. Karahashi, Keizo Ishii, Yukihiro Takahashi, Yoshihito Funaki, Hiromichi Yamazaki, Atsuki Terakawa, Youhei Kikuchi, Shigeo Matsuyama, Nobuhiko Ito, K. Sera, T. Kawamura, Y. Miura, Kazue Mizuno
Rok vydání:	2014
Předmět:	Cisplatin Polymeric micelles Significant difference Radiochemistry Analytical chemistry Normal tissue chemistry.chemical_element chemistry Elemental analysis Drug delivery medicine Platinum Solid tumor medicine.drug
Zdroj:	International Journal of PIXE. 24:41-47
ISSN:	1793-6616 0129-0835
DOI:	10.1142/s0129083514500053
Popis:	We report an elemental analysis of murine solid tumors treated with cisplatin-incorporated polymeric micelles (NC-6004) to evaluate the concentration of the drug in the tumor tissue using conventional particle-induced X-ray emission (PIXE) analysis, as well as the spatial distribution in the tumor section using sub-millimeter PIXE analysis. The results reveal that the platinum concentration in the tumor treated with NC-6004 was higher than in that treated with cisplatin, whereas no significant difference was found in platinum concentration between NC-6004 and cisplatin samples in the normal tissue. This suggests that NC-6004 can both provide therapeutic efficacy and reduce the side effects caused by conventional treatment using cisplatin. These results show that PIXE analysis is a powerful tool for research into drug delivery systems.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::639ee9e4d79a9a8d2682a19badc73e3a https://doi.org/10.1142/s0129083514500053 Zobrazit plný text záznamu Plný text ve formátu PDF