Regional anatomy of the pedunculopontine nucleus: Relevance for deep brain stimulation

Autor:	Marie-Pierre Fournier-Gosselin, Andres M. Lozano, Jean A. Saint-Cyr, Nir Lipsman, Clement Hamani
Rok vydání:	2013
Předmět:	Regional anatomy Stereotactic surgery Deep brain stimulation Parkinson's disease medicine.medical_treatment Stimulation Human brain medicine.disease Gait (human) medicine.anatomical_structure Neurology medicine Neurology (clinical) Psychology Neuroscience Pedunculopontine nucleus
Zdroj:	Movement Disorders. 28:1330-1336
ISSN:	0885-3185
DOI:	10.1002/mds.25620
Popis:	The pedunculopontine nucleus (PPN) is currently being investigated as a potential deep brain stimulation target to improve gait and posture in Parkinson's disease. This review examines the complex anatomy of the PPN region and suggests a functional mapping of the surrounding nuclei and fiber tracts that may serve as a guide to a more accurate placement of electrodes while avoiding potentially adverse effects. The relationships of the PPN were examined in different human brain atlases. Schematic representations of those structures in the vicinity of the PPN were generated and correlated with their potential stimulation effects. By providing a functional map and representative schematics of the PPN region, we hope to optimize the placement of deep brain stimulation electrodes, thereby maximizing safety and clinical efficacy. © 2013 International Parkinson and Movement Disorder Society
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::639aa41375df94805d941978cacfe658 https://doi.org/10.1002/mds.25620 Zobrazit plný text záznamu Plný text