Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons
| Autor: | Victor M. Luna, Swati Jain, Liam Drew, Melody V. Wu, Christine A. Denny, Megan A. Cloidt, René Hen, Helen E. Scharfman, Mazen A. Kheirbek |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
endocrine system Cognitive Neuroscience Dentate gyrus Neurogenesis Stimulation Optogenetics Hippocampal formation Biology Inhibitory postsynaptic potential 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Inhibitory modulation GABAergic sense organs Neuroscience hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery |
| Zdroj: | Hippocampus. 26:763-778 |
| ISSN: | 1050-9631 |
| DOI: | 10.1002/hipo.22557 |
| Popis: | Robust incorporation of new principal cells into pre-existing circuitry in the adult mammalian brain is unique to the hippocampal dentate gyrus (DG). We asked if adult-born granule cells (GCs) might act to regulate processing within the DG by modulating the substantially more abundant mature GCs. Optogenetic stimulation of a cohort of young adult-born GCs (0 to 7 weeks post-mitosis) revealed that these cells activate local GABAergic interneurons to evoke strong inhibitory input to mature GCs. Natural manipulation of neurogenesis by aging-to decrease it-and housing in an enriched environment-to increase it-strongly affected the levels of inhibition. We also demonstrated that elevating activity in adult-born GCs in awake behaving animals reduced the overall number of mature GCs activated by exploration. These data suggest that inhibitory modulation of mature GCs may be an important function of adult-born hippocampal neurons. (c) 2015 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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