Bayesian Prediction of Down Syndrome Based on Maternal Age and Four Serum Markers

Autor:	Raquel Montes Diez, David Ríos Insua, J. M. Marín
Rok vydání:	2004
Předmět:	Pregnancy Down syndrome medicine.medical_specialty Fetus medicine.diagnostic_test Screening test Obstetrics business.industry Diagnostic test medicine.disease Bioinformatics Miscarriage medicine Amniocentesis business Serum markers
Zdroj:	Biological and Medical Data Analysis ISBN: 9783540239642 ISBMDA
Popis:	Screening tests have been designed to identify women at increased risk of having a Down syndrome pregnancy. These tests have no risks of miscarriage, but they are not able to determine with certainty whether a fetus is affected. Diagnostic tests such as amniocentesis, on the other hand, are extremely accurate at identifying abnormalities in the fetus, but carry some risk of miscarriage, making it inappropriate to examine every pregnancy in this way. Muller et al.(1999), compares six software packages that calculate Ds risk, concluding that substantial variations are observed among them. In this paper, we provide a Bayesian reanalysis of the current quadruple screening test, based on maternal age and four serum markers (afp, uE3, hCG and DIA), which suggests the need to reevaluate more carefully actual recomendations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::637b657dbda884a703c8121dc018a864 https://doi.org/10.1007/978-3-540-30547-7_10 Zobrazit plný text záznamu