Elevated Tear IgG And Conjunctival Plasma Cell Infiltrate in a Graft Versus Host Disease Patient

Autor:	Steven L Maskin, Richard W. Yee, Andrew W. Lawton, Kwok-Wai Lam, Kurt F. Heitman
Rok vydání:	1988
Předmět:	Pathology medicine.medical_specialty business.industry Mucin Status post Plasma cell medicine.disease Transplantation Ophthalmology Elevated igg Leukemia surgical procedures operative Graft-versus-host disease medicine.anatomical_structure immune system diseases Medicine Tears business
Zdroj:	Cornea. 7:57
ISSN:	0277-3740
DOI:	10.1097/00003226-198801000-00008
Popis:	Two patients developed graft versus host disease (GvHD) following allogeneic bone marrow transplantation for leukemia. One patient developed acute GvHD 12 days after transplantation, and the second developed chronic GvHD 100 days after transplantation. Tear analysis and conjunctival impression cytology were performed. The results were compared to a normal control and to another patient who was 18 months status post bone marrow transplantation with successfully treated GvHD. Tear sampling on the patient with chronic GvHD revealed greatly elevated IgG levels with an inverse IgG to IgA ratio, as compared with normals. In addition, two of three leukemia patients demonstrated decreased mucin levels in tears. Conjunctival impression cytology from the patient with chronic GvHD revealed an abundance of plasma cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6375640eef2efc6fcedc6f2dd0def5b5 https://doi.org/10.1097/00003226-198801000-00008 Zobrazit plný text záznamu