The absolute configuration of an intermediate cyclic sulfoximine in the asymmetric synthesis of transition-state analog inhibitors of γ-glutamylcysteine synthetase

Autor:	N. Tokutake, A. Yamano, T. Irie, J. Hiratake, J.-I. Oda
Rok vydání:	1999
Předmět:	Transition state analog Stereochemistry Chemistry Atom Absolute configuration Enantioselective synthesis Molecule General Medicine Crystal structure Glutamylcysteine Synthetase General Biochemistry Genetics and Molecular Biology
Zdroj:	Acta Crystallographica Section C Crystal Structure Communications. 55:1598-1599
ISSN:	0108-2701
DOI:	10.1107/s0108270198016436
Popis:	The crystal structure of a cyclic sulfoximine, 2-amino-4-(4-ethyl-1,3-dioxo-4,5-dihydro-1,2-thiazol-1-yl)butanoic acid, C 9 H 16 N 2 O 4 S, was determined to ascertain its stereochemistry. The absolute configuration of the chiral S atom was S on the basis of the (S)-α-carbon derived from the synthetic precursor, L-homocysteine.
Databáze:	OpenAIRE
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