The neurology and neuropathology of coeliac disease
| Autor: | Adrian J Wills |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pathology
medicine.medical_specialty Pediatrics Histology Ataxia Neurology business.industry Neuropathology Neurological disorder medicine.disease digestive system diseases Coeliac disease Pathology and Forensic Medicine Peripheral neuropathy Physiology (medical) medicine Dementia Neurology (clinical) medicine.symptom business Myoclonus |
| Zdroj: | Neuropathology and Applied Neurobiology. 26:493-496 |
| ISSN: | 0305-1846 |
| DOI: | 10.1046/j.0305-1846.2000.00292.x |
| Popis: | A number of neurological syndromes have been described in association with coeliac disease. These include disorders of the central nervous system encompassing epilepsy, myoclonus, ataxia, internuclear opthalmoplegia, multifocal leukoencephalopathy and dementia. Most of these associated conditions show a poor response to gluten restriction. Peripheral neuropathies, of axonal and demyelinating types, have also been reported and may respond to elimination of gluten from the diet. The mechanism underlying these processes remains obscure but may be immunological or related to trace vitamin deficiencies. Controversially, it has also been claimed that occult coeliac disease accounts for a substantial proportion of patients with neurological dysfunction of unknown cause. Some authorities recommend that cryptogenic ataxias and neuropathies should be routinely screened for the presence of gluten-sensitivity but this remains contentious and has not been universally accepted. This review will attempt to review the clinical and pathological findings in this condition and speculate on pathogenesis and directions for future research. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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