A new synthetic route to macrocycles : Synthesis of large ring enaminolactones

Autor:	F. Jourdain, J. C. Pommelet
Rok vydání:	1994
Předmět:	Nucleophilic addition Organic Chemistry Hydroxy group Thermal decomposition Ring (chemistry) Biochemistry Medicinal chemistry chemistry.chemical_compound Stereospecificity chemistry Intramolecular force Drug Discovery Nucleophilic substitution Organic chemistry Pyrolysis
Zdroj:	Tetrahedron Letters. 35:1545-1548
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)76754-2
Popis:	Macrocyclic enaminolactones 5 are prepared in three steps from commercialy available chloroalcohols 1 . The cyclization step is performed by intramolecular nucleophilic addition of the hydroxy group to an aminomethyleneketene generated by thermolysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::636e48138febd03ee6e711aee24b8aee https://doi.org/10.1016/s0040-4039(00)76754-2 Zobrazit plný text záznamu