Effect of Sucralfate onHelicobacter pyloriand Severity of Gastritis in Patients with Duodenal Ulcer
| Autor: | J. A. Louw, Trevor A. Winter, M Callanan, Marks In, Lucke W, K. Jaskiewicz |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test biology business.industry Gastroenterology Helicobacter pylori biology.organism_classification Endoscopy Duodenal ulcer Sucralfate Internal medicine medicine In patient Gastritis medicine.symptom business Prospective cohort study Antrum medicine.drug |
| Zdroj: | Scandinavian Journal of Gastroenterology. 30:85-88 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365529509090279 |
| Popis: | Background: Duodenal ulcer relapse rates have been reported to be lower following healing with sucralfate. The question arises whether this is related to an effect on Helicobacter pylori. Methods: In order to investigate this possibility, 43 patients with active duodenal ulcer were entered into a study. Endoscopy was performed at entry, following 6 weeks' treatment with sucralfate 1 g q.i.d., and at 4 and 12 weeks of post-documented healing. Antral and gastric corpus biopsies were taken for assessment of H. pylori status (CLOtest), density of infection, and severity of gastritis. In addition, 14C urea breath tests (UBT) were performed. Results: Sucralfate therapy induced a significant decrease in the density of H. pylori infection, with a trend to improvement of the gastritis in the antrum, but not in the corpus. However, all patients remained CLOtest positive, and the overall gastric urease activity was unchanged following therapy. These effects did not appear to influence either initial duodenal ulcer h... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|