Preparation of immobilized swainsonine analogs on solid support

Autor:	Tanya M Jewell, William H. Pearson, Luyi Guo
Rok vydání:	2002
Předmět:	Mannosidase symbols.namesake Swainsonine chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Drug Discovery symbols Golgi apparatus Biochemistry Acyl group
Zdroj:	Tetrahedron Letters. 43:2175-2178
ISSN:	0040-4039
Popis:	Golgi α-mannosidase II and lysosomal mannosidase are examples of biologically important α-mannosidases that are difficult to purify. Swainsonine is an effective inhibitor of these α-mannosidases. In this report, analogs of swainsonine bearing an aminoalkyl group at C3 or C6 are synthesized and coupled with Affi-Gel 10 to prepare affinity matrices that may be useful for the preparation of α-mannosidases. Model ligands, where the aminoalkyl group is capped with an acyl group, are evaluated against a commercial α-mannosidase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::636a48f1d45924dc63807af3bfdcfbc9 https://doi.org/10.1016/s0040-4039(02)00254-x Zobrazit plný text záznamu Full Text from ScienceDirect