EFFECTS OF TELMISARTAN ON PLASMA INTERLEUKIN-6 AND C-REACTIVE PROTEIN LEVELS IN MONOSODIUM GLUTAMATE-INDUCED OBESITY IN WISTAR ALBINO RATS

Autor:	Ravichandra, Sriram Bs, Rajendra Holla, KM Venkatesh
Rok vydání:	2020
Předmět:	Pharmacology medicine.medical_specialty biology Chemistry Monosodium glutamate C-reactive protein Pharmaceutical Science medicine.disease Obesity chemistry.chemical_compound Endocrinology Internal medicine medicine biology.protein Pharmacology (medical) Telmisartan Interleukin 6 medicine.drug
Zdroj:	Asian Journal of Pharmaceutical and Clinical Research. :146-148
ISSN:	2455-3891 0974-2441
Popis:	Objectives: The objectives of this study were to evaluate the effects of telmisartan on plasma interleukin (IL)-6 and C-reactive protein (CRP) levels in monosodium glutamate (MSG)-induced obesity in Wistar albino rats. Methods: MSG at the dose of 500 mg/kg body weight is dissolved in distilled water and administered for 22 days. On the 9th day, telmisartan 7.5 mg/kg body weight is administered. After completion of experiment, body weight and biochemical parameters such as plasma IL-6 and CRP levels are measured using enzyme-linked immunosorbent assay. Results: Telmisartan significantly decreased plasma IL-6 and CRP levels in MSG-treated obese rats. Conclusion: Telmisartan, probably through its peroxisome proliferator-activated receptor-γ agonistic activity, produces significant anti-obesity effects in rats and may help in treating obese patients with metabolic syndrome.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::636631bd20eba959e2a090b69d1e0081 https://doi.org/10.22159/ajpcr.2020.v13i6.37286 Zobrazit plný text záznamu