Aneuploidy as a promoter and suppressor of malignant growth
| Autor: | Jason M. Sheltzer, Erin L. Sausville, Klaske M. Schukken, Vishruth Girish, Oluwadamilare A. Adebambo, Anand Vasudevan |
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| Rok vydání: | 2021 |
| Předmět: |
Tumor microenvironment
Applied Mathematics General Mathematics Aneuploidy Cancer Context (language use) Biology medicine.disease medicine.disease_cause Phenotype Metastasis law.invention 03 medical and health sciences 0302 clinical medicine law 030220 oncology & carcinogenesis medicine Cancer research Suppressor Carcinogenesis |
| Zdroj: | Nature Reviews Cancer. 21:89-103 |
| ISSN: | 1474-1768 1474-175X |
| DOI: | 10.1038/s41568-020-00321-1 |
| Popis: | Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years, but the connection between chromosomal errors and malignant growth has remained obscure. New evidence emerging from both basic and clinical research has illuminated a complicated relationship: despite its frequency in human tumours, aneuploidy is not a universal driver of cancer development and instead can exert substantial tumour-suppressive effects. The specific consequences of aneuploidy are highly context dependent and are influenced by a cell's genetic and environmental milieu. In this Review, we discuss the diverse facets of cancer biology that are shaped by aneuploidy, including metastasis, drug resistance and immune recognition, and we highlight aneuploidy's distinct roles as both a tumour promoter and an anticancer vulnerability. |
| Databáze: | OpenAIRE |
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