| Autor: |
Novoa, María L., Yelisbeth Escalante, Maldonado, Liliana, Galindo-Castro, Iván, Annamil Álvarez, Figarella, Katherine, Marsiccobetre, Sabrina, Arocha, Irina, Jais Nieves, Salazar, Franklin, Gámez, Carlos, Canudas, Nieves, Tropper, Eleonora, González, Teresa, Villamizar, José E. |
| Rok vydání: |
2014 |
| DOI: |
10.6084/m9.figshare.1121641.v12 |
| Popis: |
13,14-Dihydroxy-8,11,13-podocarpatrien-7-one (1) and a series of ring C aromatic diterpene derivatives were synthesised from (+)-manool (4) and evaluated for their cytotoxic, leishmanicidal and trypanocidal activities. Our results indicated that compound 1 and other podocarpane-type intermediates are cytotoxic. Cleavage of C6–C7 bond of compound 7 improved cytotoxic activity, indicating that, in particular, the 6,7-seco-podocarpane-type compound 20 might serve as a lead compound for further development. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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