Methylene C(sp3)–H Arylation of Aliphatic Ketones Using a Transient Directing Group
| Autor: | Jin-Quan Yu, Kai Hong, Hojoon Park |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
inorganic chemicals
chemistry.chemical_classification Ketone 010405 organic chemistry Chemistry chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound Group (periodic table) Organic chemistry Chelation Methylene Palladium |
| Zdroj: | ACS Catalysis. 7:6938-6941 |
| ISSN: | 2155-5435 |
| Popis: | Palladium-catalyzed methylene β-C(sp3)–H arylation of aliphatic ketones using a transient directing group is developed. The use of α-benzyl β-alanine directing group that forms a six-membered chelation with palladium is crucial for promoting the methylene C(sp3)–H bond activation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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