Controlled drug release behavior of 5-aminosalicylic acid using polyacrylamide grafted oatmeal (OAT-g-PAM): a pH-sensitive drug carrier
Autor: | Srijita Bharti, Sumit Mishra |
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Rok vydání: | 2018 |
Předmět: |
Chromatography
Aminosalicylic acid Polymers and Plastics Polyacrylamide 02 engineering and technology General Chemistry Buffer solution 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Acrylamide Drug delivery Materials Chemistry Radical initiator 0210 nano-technology Drug carrier Ceric ammonium nitrate |
Zdroj: | Polymer Bulletin. 76:813-824 |
ISSN: | 1436-2449 0170-0839 |
DOI: | 10.1007/s00289-018-2407-x |
Popis: | In the present investigation, we have evaluated the in vitro drug release of 5-aminosalicylic acid (5-ASA) using polyacrylamide grafted oatmeal (OAT-g-PAM). The graft co-polymer was synthesized by following free radical co-polymerization pathway using acrylamide as a monomer and ceric ammonium nitrate as a free radical initiator in the presence of microwave. The matrix tablet was prepared using the different grades of developed graft co-polymers following standard protocol. In vitro release phenomena of 5-ASA from the prepared matrix tablet up to 12 h in different buffer solution, i.e., pH 2.0, 7.0 and 7.4, an ideal condition for colon specific drug delivery was studied. The release rate of 5-ASA can be controlled efficiently by tuning the pH value. The drug release kinetic of 5-ASA from different matrix tablet was evaluated on the basis of in vitro controlled drug release results. The result indicates that the novel pH-sensitive matrices under study showing Fickian diffusion mechanism and potentially constructive for colonic drug delivery system. |
Databáze: | OpenAIRE |
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